Molecular biology of Philadelphia chromo
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S. Eridani; L. M. Wiedemann; L. C. Chan; R. G. Dalton; K. K. Karhi
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Article
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1987
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Springer
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English
β 447 KB
In classical t(9;22) translocation, as observed in chronic granulocytic leukemia (CGL), a hybrid DNA unit is produced, including a rearranged PHL gene, previously known as bcr (breakpoint cluster region) plus the translocated c-abl gene from chromosome 9: a hybrid bcr-abl protein, p210 is formed, wi