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Molecular Basis of Immortalization of Human Mesenchymal Stem Cells by Combination of p53 Knockdown and Human Telomerase Reverse Transcriptase Overexpression

✍ Scribed by Liu, Tong Ming; Ng, Wei Ming; Tan, Hwee San; Vinitha, Denslin; Yang, Zheng; Fan, Jia Bing; Zou, Yu; Hui, James H.; Lee, Eng Hin; Lim, Bing


Book ID
120066054
Publisher
Mary Ann Liebert
Year
2013
Tongue
English
Weight
854 KB
Volume
22
Category
Article
ISSN
1547-3287

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## Abstract Normal somatic cells possess a finite life span owing to replicative senescence. Telomerase functions as a potential regulator of senescence in various cells. Expression level of human telomerase reverse transcriptase (hTERT) is correlated with telomerase activity and cellular immortali