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Molecular Basis of a Mutational Hot Spot in the Lysozyme Gene of Bacteriophage T4

✍ Scribed by STREISINGER, GEORGE; (EMRICH) OWEN, JOYCE; NEWTON, JUDITH; TSUGITA, AKIRA; INOUYE, MASAYORI; OKADA, YOSHIMI


Book ID
109682030
Publisher
Nature Publishing Group
Year
1972
Tongue
English
Weight
421 KB
Volume
236
Category
Article
ISSN
0028-0836

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A hotspot for transition mutations in th
✍ Singer, Britta Swebilius πŸ“‚ Article πŸ“… 1984 πŸ› Springer 🌐 English βš– 729 KB

We have previously demonstrated that the sequence 5'TGGCAA 3' located at codons 32-33 of the rIIB gene of bacteriophage T4 is a hotspot for transition mutations (Nelson et al. 1981). Here I report the properties of the same TGGCAA sequence introduced into the gene at codons 11-12. The sequence is hi