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Is the nucleotide 654 of the geisolin gene a mutational hot spot?

✍ Scribed by Tiina Paunio; Yoshihide Sunada; Robert Steiner; Sari Kiuru; Hideo Makishita; Shu-ichi lkeda; Tomoyuki Uemichi; Merril D. Benson; Jorma Palo; L. Peltonen

Book ID
116168706
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
97 KB
Volume
6
Category
Article
ISSN
0960-8966

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A mutational hot spot in the p53 gene is
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✍ Hideaki Oda; Yoko Nakatsuru; Yasuo Imai; Haruhiko Sugimura; Takatoshi Ishikawa πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 French βš– 918 KB

## Abstract Hepatoblastomas generally appear in children aged 2 or 3 years old and arise from apparently normal, noncirrhotic liver. To elucidate any possible role of p53 mutations in their genesis, we amplified and sequenced exons 5 to 8 of the p53 gene in 10 cases of hepatoblastoma. Somatic mutat