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Molecular basis for the interaction of four different classes of substrates and inhibitors with human aromatase

✍ Scribed by Yanyan Hong; Michael Cho; Yate-Ching Yuan; Shiuan Chen


Book ID
113488445
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
887 KB
Volume
75
Category
Article
ISSN
0006-2952

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ChemInform Abstract: Evidence for New No
✍ P. AUVRAY; S. MOSLEMI; P. SOURDAINE; S. GALOPIN; G.-E. SERALINI; C. ENGUEHARD; P πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 30 KB πŸ‘ 2 views

Site. -Depending on the reaction time, indan-1-ones (III) and inden-1-ones (V) are prepared. They are further used to study the active binding site of human aromatase inhibitors. Two compounds (Vb) and (Vc) are good inhibitors of human aromatase whereas they weakly inhibit the equine enzyme.