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Molecular Basis for p38 Protein Kinase Inhibitor Specificity

โœ Scribed by Lisnock, JeanMarie; Tebben, Andy; Frantz, Betsy; O'Neill, Edward A.; Croft, Gist; O'Keefe, Stephen J.; Li, Bing; Hacker, Candice; de Laszlo, Stephen; Smith, Anthony; Libby, Brian; Liverton, Nigel; Hermes, Jeffrey; LoGrasso, Philip


Book ID
120399741
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
186 KB
Volume
37
Category
Article
ISSN
0006-2960

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Structural basis for the high-affinity b
โœ Sack, John S. ;Kish, Kevin F. ;Pokross, Matthew ;Xie, Dianlin ;Duke, Gerald J. ; ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› International Union of Crystallography ๐ŸŒ English โš– 635 KB

The crystal structure of unphosphorylated p38 MAP kinase complexed with a representative pyrrolotriazine-based inhibitor led to the elucidation of the high-affinity binding mode of this class of compounds at the ATP-binding site. The ligand binds in an extended conformation, with one end interacting