## Abstract The frequent occurrence of ochratoxin A (OA) in food and feed commodities and the high incidence of human exposure, as confirmed by different surveillance studies initiated several investigations devoted to elucidating the molecular mechanisms underlying OA toxicity. Previous studies in
Molecular Aspects of the Transport and Toxicity of Ochratoxin A
β Scribed by Jian Dai; Gyungse Park; Jennifer L Perry; Yuri V. Il'ichev; Daniel A. J. Bow; John B. Pritchard; Virginie Faucet; Annie Pfohl-Leszkowicz; Richard A. Manderville; John D. Simon
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 8 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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## Abstract The aim of this study was to find out whether very low doses of nephrotoxic and hepatotoxic mycotoxins ochratoxin A (OTA) and fumonisin B~1~ (FB~1~) induce oxidative stress in rat kidney and liver and whether their effect is synergistic. Rats were treated orally with OTA (5 ng/kg b.w. a
## Abstract Ochratoxin A (OTA) is a mycotoxin produced by different fungi. The most pronounced adverse effect of OTA is hepatonephrotoxicity. Melatonin (MEL) has an antioxidant effect and has freeβradical scavenger properties. The effects of OTA on heart and lung tissue and possible ameliorating ef