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MOLECULAR ASPECTS OF ALCOHOL METABOLISM: Transcription Factors Involved in Early Ethanol-Induced Liver Injury

โœ Scribed by Nagy, Laura E.


Book ID
120332612
Publisher
Annual Reviews
Year
2004
Tongue
English
Weight
245 KB
Volume
24
Category
Article
ISSN
0199-9885

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Chronic alcohol administration increases gut-derived endotoxin in the portal blood, which activates Kupffer cells and causes liver injury. Mice (C3H/HeJ) with mutations in toll-like receptor 4 (TLR4) are hyporesponsive to endotoxin. To test the hypothesis that TLR4 is involved in early alcohol-induc