Molecular Aspects of Aging (Understanding Lung Aging) || Aging Mesenchymal Stem Cells in Lung Disease
โ Scribed by Rojas, Mauricio; Meiners, Silke; Le Saux, Claude Jourdan
- Book ID
- 126811426
- Publisher
- John Wiley & Sons, Inc
- Year
- 2014
- Weight
- 176 KB
- Category
- Article
- ISBN
- 1118396243
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## Abstract The incidence of lung fibrosis increases with age. Aging is associated with modifications in the intracellular and extracellular environment including alteration of the extracellular matrix, imbalance of the redox state, accumulation of senescent cells and potential alteration of the re
## Background A hot new topic in medical treatment is the use of mesenchymal stem cells (MSC) in therapy. The low frequency of this subpopulation of stem cells in bone marrow (BM) necessitates their in vitro expansion prior to clinical use. We evaluated the effect of long term culture on the senesc