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Aging and lung injury repair: A role for bone marrow derived mesenchymal stem cells

✍ Scribed by Ana L. Mora; Mauricio Rojas

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
148 KB
Volume
105
Category
Article
ISSN
0730-2312

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✦ Synopsis

Abstract

The incidence of lung fibrosis increases with age. Aging is associated with modifications in the intracellular and extracellular environment including alteration of the extracellular matrix, imbalance of the redox state, accumulation of senescent cells and potential alteration of the recruitment of bone marrow mesenchymal stem cells. The combination of these senescence‐related alterations in the lung and in bone marrow progenitor cells might be responsible of the higher susceptibility to lung fibrosis in elderly individuals. The understanding of these age related changes must be considered in the rationale for the development of therapeutic interventions to control lung injury and fibrosis. J. Cell. Biochem. 105: 641–647, 2008. © 2008 Wiley‐Liss, Inc.

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