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Molecular and structural aspects of clinically relevant mutations related to the approved non-nucleoside inhibitors of HIV-1 reverse transcriptase

✍ Scribed by Stefano Alcaro; Claudia Alteri; Anna Artese; Francesca Ceccherini-Silberstein; Giosuè Costa; Francesco Ortuso; Lucia Parrotta; Carlo Federico Perno; Valentina Svicher


Book ID
116413326
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
823 KB
Volume
14
Category
Article
ISSN
1368-7646

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## Abstract An extended spectrum of HIV‐1 reverse‐transcriptase (RT) mutations in HAART‐treated patients has been recently described. To verify the possible association of previously unreported RT mutations with a decrease of phenotypic susceptibility to nucleoside (NRTIs) and non‐nucleoside (NNRTI