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Molecular and cellular biology of basal cell carcinoma

โœ Scribed by Tony Dicker; Gregory Siller; Nicholas Saunders

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
225 KB
Volume
43
Category
Article
ISSN
0004-8380

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โœฆ Synopsis

SUMMARY

The finding of mutations in the PTCH gene in both Gorlin's syndrome and sporadic basal cell carcinomas has significantly advanced our understanding of the molecular defects that lead to the formation of these tumours. Knowledge of the specific molecular and functional changes that have taken place in these tumours will help us devise more defined therapies, as well as give us a better understanding of normal molecular pathways involved in skin development and function. The following is a summary of our current understanding of the molecular and cellular biology of basal cell carcinoma.

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