Molecular and cellular biology of malaria

✍ Scribed by Richard Braun

• Publisher: John Wiley and Sons
• Year: 1988
• Tongue: English
• Weight: 824 KB
• Volume: 8
• Category: Article
• ISSN: 0265-9247
• DOI: 10.1002/bies.950080605

✦ Synopsis

Thanks to the extensive use of recombinant DNA technology and immunological methods, much insight into cellular functions of the human malaria parasite Plasmodium falciparum has been gained since it was learnt ten years ago how to grow this organism in culture. The amino acid sequence of over a dozen surface proteins of the parasite and of several proteins the parasite excretes into its most important host cell, the erythrocyte, have been determined. Interestingly many of these proteins show blocks of repeated amino acids. Several proteins have been shown to be involved in specific aspects of the complex hostparasite interaction, such as penetration of host cells or increased stickiness of infected red blood cells in the blood vessels. Some of the proteins described here may be protective antigens and may become 'important in vaccine development.