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Molecular and biological properties of an interleukin-1 receptor immunoadhesin

✍ Scribed by Robert M. Pitti; Scot A. Marsters; Mary Haak-Frendscho; Gary C. Osaka; Joyce Mordenti; Steven M. Chamow; Avi Ashkenazi

Book ID
118384936
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
936 KB
Volume
31
Category
Article
ISSN
0161-5890

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A human myelomonocytic cell line, U937, produced an interleukin-1 (IL-1) receptor antagonist protein (IRAP) which was purified and partially sequenced. A complementary DNA coding for IRAP was cloned and sequenced. The mature translation product of the cDNA has been expressed in Escherichia coli and