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Molecular analysis of the retinoblastoma gene in primary ovarian cancer cells

✍ Scribed by Yie Liu; Mats Hbyman; Yisong Wang; Ursula Falkmer; Christina Hising; László Székely; Stefan Einhorn

Publisher
John Wiley and Sons
Year
1994
Tongue
French
Weight
541 KB
Volume
58
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Loss

of heterozygosity (LOH) at the site of the retinoblastoma ( R B I ) gene, at 13q14, has been shown to occur in a high proportion of ovarian cancer patients. Based on this, RB I gene inactivation was studied in primary tumor cells from I 5 patients with ovarian cancer. Structural changes as well as expression of the RBI gene were investigated. One patient had a nondisjunctional deletion at the RBI locus, and the duplicated remaining allele carried a deletion of exon 21. In another patient, without detectable structural changes of the RBI gene, no RB protein was detected. Allelic losses at the RBI locus were observed in 8/ 13 informative cases (619'0)). Our results indicate that inactivation of the RBI gene plays a role in tumor development in a minority of ovarian cancer patients. Another gene@) on 13q also seem(s) to influence malignant transformation in patients with ovarian cancer.

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