It is now believed that genes regulating apoptosis are also important variables in cancer development. Fas, a transmembrane protein of the tumour necrosis factor receptor family, is a key molecule for cell death signalling. The mutation of the primary structure of the Fas gene might also be one of t
Analysis of Fas/CD95 gene somatic mutations in ovarian cancer cell lines
β Scribed by Francesco Bertoni; Annarita Conconi; Stefania Carobbio; Claudio Realini; Anna Maria Codegoni; Emanuele Zucca; Franco Cavalli
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- French
- Weight
- 21 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0020-7136
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Resistance to CD95 (Apo-1/Fas)-mediated apoptosis is a typical feature of breast cancer cells. Recent studies identified deleterious mutations of the CD95 gene not only in a variety of B cell lymphomas but also in a number of solid tumor entities. Therefore, we amplified and sequenced selected regio
Fas, also designated as Apo-1 and CD95, is a cell membrane receptor (mFas) involved in apoptotic cell death. A soluble form (sFas) lacking the transmembrane domain due to alternative splicing has been isolated. Abnormal expression of sFas and mFas is likely to be involved in lymphoproliferative diso