Molecular Analysis of T-Cell Receptor β Genes in Cutaneous T-Cell Lymphoma Reveals Jβ1 Bias
✍ Scribed by Morgan, Suzanne M; Hodges, Elizabeth; Mitchell, Tracey J; Harris, Susan; Whittaker, Sean J; Smith, John L
- Book ID
- 110049378
- Publisher
- Nature Publishing Group
- Year
- 2006
- Tongue
- English
- Weight
- 202 KB
- Volume
- 126
- Category
- Article
- ISSN
- 0022-202X
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We report a case of human T-cell lymphotropic virus type 1 (HTLV-1)-infected adult T-cell lymphoma that has multiple chromosomal abnormalities, including the presence of an additional 7q22-36, which contains the locus of the T-cell receptor (TCR) beta chain gene. Specific TCR JplIJp2 gene rearrangem
## Abstract We studied rearrangement of human T cell receptor genes (TCR) of Cβ, Cγ, Vγ and Jγ in 34 cases of adult T cell leukemia/lymphoma (ATLL), consisting of 29 cases with monoclonally integrated HTLV‐I proviral DNA (ATLL‐W) and five without monoclonal integration (ATLL‐O), in comparison with