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Molecular Analysis of Phyllodes Tumors Reveals Distinct Changes in the Epithelial and Stromal Components

✍ Scribed by Elinor J. Sawyer; Andrew M. Hanby; Paul Ellis; Sunil R. Lakhani; Ian O. Ellis; Sue Boyle; Ian P.M. Tomlinson


Book ID
117022476
Publisher
American Society for Investigative Pathology
Year
2000
Tongue
English
Weight
338 KB
Volume
156
Category
Article
ISSN
0002-9440

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## Abstract Gastrointestinal stromal tumors (GISTs) generally harbor activating mutations in __KIT__ or platelet‐derived growth facter receptor (__PDGFRA__). Mutations in these receptor tyrosine kinases lead to dysregulation of downstream signaling pathways that contribute to GIST pathogenesis. GIS