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Molecular analysis of mutations at the tk locus of L5178Y mouse-lymphoma cells induced by ethyl methanesulphonate and mitomycin C

✍ Scribed by M.J. Davies; B.J. Phillips; P.C. Rumsby

Book ID
113194378
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
780 KB
Volume
290
Category
Article
ISSN
0027-5107

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One of the mammalian cell gene-mutation assays that has been used extensively for mutagenicity studies is the L5178Y/TK+'--3.7.2C mouse lymphoma assay Oberly et al., 19841. This assay measures forward mutation at the functionally heterozygous thymidine kinase (rk) locus based on resistance to trifl