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Molecular analysis of chromosome 22 breakpoints in adult Philadelphia-positive acute lymphoblastic leukaemia

โœ Scribed by Razelle Kurzrock; Mordechai Shtalrid; Jordan U. Gutterman; Charles A. Koller; Ronald Walters; Jose M. Trujillo; Moshe Talpaz


Book ID
114710989
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
629 KB
Volume
67
Category
Article
ISSN
0007-1048

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Molecular biology of Philadelphia chromo
โœ S. Eridani; L. M. Wiedemann; L. C. Chan; R. G. Dalton; K. K. Karhi ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› Springer ๐ŸŒ English โš– 447 KB

In classical t(9;22) translocation, as observed in chronic granulocytic leukemia (CGL), a hybrid DNA unit is produced, including a rearranged PHL gene, previously known as bcr (breakpoint cluster region) plus the translocated c-abl gene from chromosome 9: a hybrid bcr-abl protein, p210 is formed, wi