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Molecular analysis of a variant 18;22 translocation in a case of lymphocytic lymphoma

✍ Scribed by Paule Seité; Dominique Leroux; Josette Hillion; Michèle Monteil; Roland Berger; Danièle Mathieu-Mahul; Christian-Jacques Larsen

Book ID
102221172
Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
477 KB
Volume
6
Category
Article
ISSN
1045-2257

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✦ Synopsis

W e previously reported a 5' rearrangement of the BCLZ locus in a t( I8;22) variant translocation found in a lymphocytic lymphoma. Primary structure analysis of both rearranged chromosomes confirmed the localization of the breakpoint in the so-called vcr region (for variant cluster region) that encompasses Z-DNA stretches 5' of the BCL2 locus, and in between ]hi and Chi segments on the IGL locus. A 1,027 nucleotide segment from chromosome 22 was repeated on both derivative chromosomes 18q + and 22q -. This segment contained an octanucleotide that was also present in the normal chromosome I 8 close to the breakpoint. As a consequence of the translocation, a normal-sized BCLZ transcript was overexpressed in tumor cells. Genes Chrom Cancer 6:39-44 ( I 993).

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