Molecular abnormalities in the expression of HLA class-I antigens by melanoma cells
β Scribed by Zhigang Wang; Yan Cao; Claudio D'Urso; Alan N. Houghton; Soldano Ferrone
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- French
- Weight
- 377 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0020-7136
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HLA class I molecules present antigenic peptides to cytotoxic T lymphocytes and thus play an important role in immune surveillance of cells infected with virus or altered by malignant transformation. Immunochemical studies have demonstrated a marked deficiency or lack of expression of class I molecu
Loss of surface expression of class I major histocompatibility antigens is commonly observed in malignant tumors and has been considered one of the mechanisms for escape from cytotoxic T cells. However, natural killer cells kill cells lacking HLA class I antigens. In the present study, we characteri