Moenomycin a: Minimum structural requirements for biological activity

✍ Scribed by Peter Welzel; Franz Kunisch; Frithjof Kruggel; Hermann Stein; Jürgen Scherkenbeck; Aranka Hiltmann; Helmut Duddeck; Dietrich Müller; John E. Maggio; Hans-Wolfram Fehlhaber; Gerhard Seibert; Yveline van Heijenoort; Jean van Heijenoort

• Publisher: Elsevier Science
• Year: 1987
• Tongue: French
• Weight: 898 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(01)89992-0

✦ Synopsis

A stepwise degradation of the oligosaccharide part of moenomycin A (2) was performed. The degradation products were assayed for antibiotic activity both in vivo and in an E.coli cell-free system. Units E, F, G, H, and I have been found -to be essential for full biological (in vitro) activity.

_-It is suggested that 2 is a competitive inhibitor of the peptidoglycan polymerase.