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Moduratory effect of Microsomal prostaglandin E synthase-1 on multiple sclerosis

✍ Scribed by Takako Takemiya; Chisen Takeuchi; Yoh Matsumoto; Kuniko Kohyama; Satoshi Uematsu; Shizuo Akira; Kanato Yamagata; Kumiko Fumisawa


Book ID
116777901
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
84 KB
Volume
68
Category
Article
ISSN
0168-0102

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Expression of microsomal prostaglandin E
✍ M. Westman; M. Korotkova; E. af Klint; A. Stark; L. P. Audoly; L. Klareskog; A.- πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 372 KB

Objective. Microsomal prostaglandin E synthase 1 (mPGES-1) catalyzes the formation of PGE 2 from cyclooxygenase-derived PGH 2 . Microsomal PGES-1 is induced by proinflammatory cytokines and is strongly linked to conditions that result in high PGE 2 biosynthesis. PGE 2 contributes to the pathogenesis