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Effects of anti-rheumatic treatments on expression of microsomal prostaglandin E synthase-1 in rheumatoid arthritis synovium

✍ Scribed by M Korotkova, M Westman, E af Klint, A-K Ulfgren, L Klareskog…

Book ID: 120707098
Publisher: BioMed Central
Year: 2004
Tongue: English
Weight: 527 KB
Volume: 6
Category: Article
ISSN: 1478-6354
DOI: 10.1186/ar1140

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Objective. Microsomal prostaglandin E synthase 1 (mPGES-1) catalyzes the formation of PGE 2 from cyclooxygenase-derived PGH 2 . Microsomal PGES-1 is induced by proinflammatory cytokines and is strongly linked to conditions that result in high PGE 2 biosynthesis. PGE 2 contributes to the pathogenesis

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