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Modulatory effect of cyclic AMP on calcium fluxes in FRTL-5 cells

✍ Scribed by Kid Törnquist; Mikael Ahlström

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
584 KB
Volume
157
Category
Article
ISSN
0021-9541

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✦ Synopsis

In rat thyroid FRTL-5 cells, two signal-transduction pathways have been extensively investigated: the activation of adenylate cyclase and the production of CAMP, and the hydrolysis of phsophatidylinositol-4,5bisphosphate (PIP,) to inositol-1,4,5-trisphosphate (IP,) resulting in the release of sequestered calcium and an increase in cytosolic free Ca2+ ([Ca2'Ii). Several

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