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Modulation of the discriminative stimulus produced by pentylenetetrazol by centrally administered drugs

✍ Scribed by D. Benjamin; M.W. Emmett-Oglesby; H. Lal

Book ID
118955718
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
672 KB
Volume
26
Category
Article
ISSN
0028-3908

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## Abstract The effect of different ligands for the GABA‐BZD receptor and the NMDA receptor were studied in rats trained to discriminate (βˆ’)‐nicotine (1.9 ΞΌmol/kg) from saline in a standard two‐bar operant conditioning paradigm with food reinforcement. MK‐801 (0.03–0.3 ΞΌmol/kg), flumazenil (10–30 ΞΌ