ldemudia S.O., and H. Lal.: Baclofen does not block interoceptive discriminative stimulus produced by pentylenetetrazol. Drug Dev. Res. 14:85-90, 1988. Baclofen was compared with diazepam for ability to block the interoceptive discriminative stimulus produced by the anxiogenic drug pentylenetetrazo
Opioid modulation of the discriminative stimulus produced by pentylenetetrazol
β Scribed by M. W. Emmett-Oglesby; A. Herz
- Publisher
- Springer
- Year
- 1987
- Tongue
- English
- Weight
- 782 KB
- Volume
- 92
- Category
- Article
- ISSN
- 0033-3158
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The interoceptive stimulus produced by pentylenetetrazol (PTZ) is pharmacologically similar to anxiety and is used in a behavioral assay for anxiety-related stimuli (the PTZ model of anxiety). The stimulus fading technique was tested as a method to increase the sensitivity of this assay. Rats were t
## Abstract The effect of different ligands for the GABAβBZD receptor and the NMDA receptor were studied in rats trained to discriminate (β)βnicotine (1.9 ΞΌmol/kg) from saline in a standard twoβbar operant conditioning paradigm with food reinforcement. MKβ801 (0.03β0.3 ΞΌmol/kg), flumazenil (10β30 ΞΌ
Rats were trained on an FR10 schedule of food reinforcement to press one lever after pentylenetetrazol (PTZ), 20 mg/kg, IP, and an alternate lever after saline. After acute nicotine, 0.64mg/kg, SC, 35% of the rats pressed the PTZ-lever. Diazepam, 5 mg/kg, IP, blocked the stimulus produced by PTZ, an