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Modulation of the Brain Distribution of Imatinib and its Metabolites in Mice by Valspodar, Zosuquidar and Elacridar

✍ Scribed by Sébastien Bihorel; Gian Camenisch; Michel Lemaire; Jean-Michel Scherrmann

Book ID
106493131
Publisher
Springer US
Year
2007
Tongue
English
Weight
375 KB
Volume
24
Category
Article
ISSN
0724-8741

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Repeated administration of diazepam leads to remarkable accumulation of N-desmethyldiazepam in white matter structures and in subcortical areas such as thalamus, hypothalamus, and hypophysis. Diazepam and the hydroxylated metabolites were present in lesser amounts. The distribution pattern of diazep