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Modulation of the apoptotic threshold by BCL-2 antisense therapy of melanoma

✍ Scribed by B. Jansen; V. Wacheck; E. Heere-Ress; H. Schlagbauer-Wadl; C. Hoeller; T. Lucas; B. Pratscher; M. Hoermann; U. Hollenstein; H.-G. Eichler; K. Wolff; H. Pehamberger

Book ID: 117657811
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 76 KB
Volume: 37
Category: Article
ISSN: 0959-8049
DOI: 10.1016/s0959-8049(01)80440-8

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## Abstract The mistletoe lectin‐1 (ML‐1) modulates tumor cell apoptosis by triggering signaling cascades through the complex interplay of phosphorylation and __O__‐linked __N__‐acetylglucosamine (__O__‐GlcNAc) modification in pro‐ and anti‐apoptotic proteins. In particular, ML‐1 is predicted to in