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Modulation of T-Suppressor cell activity by central nervous system catecholamine depletion

✍ Scribed by R. J. Cross; W. H. Brooks; T. L. Roszman

Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
707 KB
Volume
18
Category
Article
ISSN
0360-4012

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✦ Synopsis

This study extends our previous findings, which indicate that depletion of CNS catecholamines has a marked inhibitory effect on humoral immune responsiveness. These data show that depletion of CNS catecholamines by injection of 6-hydroxydopamine (6-OHDA) into the cisterna magna in conjunction with immunization enhances the activity of a population of splenic T-suppressor cells as evidenced by the transfer of these cells to normal recipients. Increased suppressor cell activity does not result solely from 6-OHDA treatment, but rather requires concomitant immunization. Further characterization shows that these suppressor cells are not antigen specific. Hypophysectomy abrogates the effects of 6-OHDA injection suggesting that catecholamine depletion modulates immune function via the release of pituitary hormones. Thus, depletion of CNS catecholamines impairs immune responsiveness by inducing enhanced T-suppressor cell activity, providing additional evidence of the involvement of the CNS in regulation of immune responsiveness.

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