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Modulation of RIP1 ubiquitylation and distribution by MeBS to sensitize cancer cells to tumor necrosis factor α-induced apoptosis

✍ Scribed by Seungseob Kim; Nobumichi Ohoka; Keiichiro Okuhira; Kimie Sai; Tomoko Nishimaki-Mogami; Mikihiko Naito

Book ID: 108586853
Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 365 KB
Volume: 101
Category: Article
ISSN: 1347-9032
DOI: 10.1111/j.1349-7006.2010.01697.x

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## Abstract Resistance to tumor necrosis factor (TNFα)‐induced apoptosis in various cancer cells has been attributed to the activation of the transcription factor NF‐κB. Ebselen (2‐phenyl‐1,2‐benzisoselenazol‐3[2H]one)—a selenoorganic compound is known to prevent TNFα‐mediated NF‐κB activity. As gl