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Modulation of proliferation-specific and differentiation-specific markers in human keratinocytes by SMAD7

โœ Scribed by Louise Smith; Alison L Dahler; Lois L Cavanagh; Claudia Popa; Liam M Barnes; Magdalena M.M Serewko-Auret; C Fai Wong; Nicholas A Saunders


Book ID
118505872
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
337 KB
Volume
294
Category
Article
ISSN
0014-4827

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The effect of transforming growth factor-type f3 l(TGF-P) on the growth and differentiation of normal human skin keratinocytes cultured in serum-free medium was investigated. TCF-P markedly inhibited the growth of keratinocytes at the concentrations >2 ng/ml under low Ca2+ conditions (0.1 mM). Growt