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Modulation of production of hepatitis B surface antigen by a human hepatoma cell line

✍ Scribed by Massimo Clementi; Patrizia Bagnarelli; Paola Pauri; Letizia Calegari

Publisher: John Wiley and Sons
Year: 1984
Tongue: English
Weight: 371 KB
Volume: 13
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.1890130202

No coin nor oath required. For personal study only.

✦ Synopsis

Three drugs were assayed for their capacity to inhibit hepatitis B surface antigen (HBsAg) production by the PLC/PRF/5 human hepatoma cell line. The effect on cell growth and HBsAg production of Cordycepin, 6-azauridine, and Hygromicin B is reported. Hygromicin B, a translation inhibitor unable to penetrate normal cells, greatly reduced HBsAg production by growing and confluent cells.

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