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Modulation of PI3K/Akt pathway by E1a mediates sensitivity to cisplatin

✍ Scribed by Viniegra, Juan Guinea; Losa, Javier Hernández; Sánchez-Arévalo, Victor Javier; Cobo, Carlos Parada; Soria, Victor Manuel Fernández; y Cajal, Santiago Ramón; Sánchez-Prieto, Ricardo


Book ID
110067077
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
172 KB
Volume
21
Category
Article
ISSN
0950-9232

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## Abstract Multidrug resistance (MDR) is one of the main reasons for failure of cancer therapy. It may be mediated by overexpression of ATP‐dependent efflux pumps or by alterations in survival or apoptotic pathways. Fragments generated by enzymatic degradation of hyaluronan (oHA) were able to modu