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Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways

✍ Scribed by Rommel, Christian; Bodine, Sue C.; Clarke, Brian A.; Rossman, Roni; Nunez, Lorna; Stitt, Trevor N.; Yancopoulos, George D.; Glass, David J.

Book ID
109912144
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
487 KB
Volume
3
Category
Article
ISSN
1465-7392

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## Abstract Skeletal muscle cells are hypertrophied by mechanical stresses, but the underlying molecular mechanisms are not fully understood. Two signaling pathways, phosphatidylinositol 3‐kinase (PI3K)/Akt to target of rapamycin (TOR) and extracellular signal–regulated kinase kinase (MEK) to extra