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Modulation of lymphokine-activated killer cell-mediated cytotoxicity by estradiol and tamoxifen

✍ Scribed by Edward Baral; Eva Nagy; Istvan Berczi

Publisher: John Wiley and Sons
Year: 1996
Tongue: French
Weight: 580 KB
Volume: 66
Category: Article
ISSN: 0020-7136
DOI: 10.1002/(sici)1097-0215(19960410)66:2<214::aid-ijc13>3.0.co;2-c

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✦ Synopsis

The effect of tamoxifen (TX) and estradiol (E2) on interleukin-2 (IL-2)-activated killer (LAK) cell-mediated cytotoxicity was examined using spleen cells of Fisher 344 rats as the source of effectors and P815 murine mastocytoma cells as targets.

Treatment of target cells with either TX or E2 for 4 or 18 hr rendered them highly sensitive to I A K cell-mediated lysis. When TX and E2 were applied jointly, cytotoxicity remained at the level of TX treatment alone. The cytotoxic potential of IL-2-primed LAK cells was not modified consistently by TX and

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