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Modulation of leukotriene synthesis and actions by synthetic derivatives of arachidonic acid

โœ Scribed by J.Bryan Smith; David M. Roth; Allan M. Lefer; Nicos A. Petasis; K.C. Nicolaou

Book ID
119050138
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
351 KB
Volume
29
Category
Article
ISSN
0090-6980

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New synthetic routes to leukotrienes and
New synthetic routes to leukotrienes and other arachidonate derived epoxy eicosatetraenoic acids (epete's). Exclusion of the hydroxy epoxide pathway for leukotriene biosynthesis
โœ E.J. Corey; Mukund M. Mehrotra; John R. Cashman ๐Ÿ“‚ Article ๐Ÿ“… 1983 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 225 KB

Synthetic hydroxy epoxides 2 and 5 have been utilized for the synthesis of the methyl esters of leukotriene A (4) and 14,15-EPETE ( 6) and for the demonstration that the acid corresponding to 3 is not an intermediaG in leukotriene biosGthesis.