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New synthetic routes to leukotrienes and other arachidonate derived epoxy eicosatetraenoic acids (epete's). Exclusion of the hydroxy epoxide pathway for leukotriene biosynthesis

✍ Scribed by E.J. Corey; Mukund M. Mehrotra; John R. Cashman


Book ID
104250263
Publisher
Elsevier Science
Year
1983
Tongue
French
Weight
225 KB
Volume
24
Category
Article
ISSN
0040-4039

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✦ Synopsis


Synthetic hydroxy epoxides 2 and 5 have been utilized for the synthesis of the methyl esters of leukotriene A (4) and 14,15-EPETE ( 6) and for the demonstration that the acid corresponding to 3 is not an intermediaG in leukotriene biosGthesis.