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Modulation of intracellular protein activity at level of protein folding by beta-turn engineering

✍ Scribed by Bharat Madan,Sun-Gu Lee

Book ID
126364679
Publisher
The Korean Society for Biotechnology and Bioengineering
Year
2014
Tongue
English
Weight
526 KB
Volume
19
Category
Article
ISSN
1226-8372

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The transcription factor p53 controls the proliferation and survival of cells exposed to DNA damage. The specific DNA-binding domain of p53 (residues 102-292) has a complex tertiary structure that is stabilized by zinc. In this study, we showed that exposure of cultured cells to the membrane-permeab