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Modulation of indoleamine-2,3-dioxygenase expression and activity by HIV-1 in human macrophages

✍ Scribed by Benjamin Manéglier; Benoit Malleret; Gilles J. Guillemin; Odile Spreux-Varoquaux; Philippe Devillier; Christine Rogez-Kreuz; Fabrice Porcheray; Patrice Thérond; Dominique Dormont; Pascal Clayette


Book ID
111194616
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
313 KB
Volume
23
Category
Article
ISSN
0767-3981

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Inhibition of indoleamine 2,3-dioxygenas
✍ Colin R. MacKenzie; Ralf Langen; Osamu Takikawa; Walter Däubener 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 142 KB

Induction of indoleamine 2,3-dioxygenase (IDO) by IFN-+ results in growth inhibition of Toxoplasma and Chlamydia spp. as well as tumor cells. This is caused by the degradation, and therefore depletion, of L-tryptophan necessary for cell protein synthesis. Human macrophages stimulated with IFN-+ expr