The Cystine/Glutamate Antiporter Regulates the Functional Expression of Indoleamine 2,3-Dioxygenase in Human Dendritic Cells
✍ Scribed by J. A. D’Angelo; M. L. Mattox; E. Fiebiger; B. L. Dickinson
- Book ID
- 117948056
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 129 KB
- Volume
- 76
- Category
- Article
- ISSN
- 0300-9475
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## Abstract ## Objective Indoleamine 2,3 dioxygenase (IDO) is a catabolic enzyme that initiates the kynurenine pathway of tryptophan degradation and has immunomodulatory properties. The aim of this study was to investigate the regulation of collagen‐induced arthritis by tryptophan catabolism media
## Abstract Indoleamine 2,3‐dioxygenase (IDO) is the rate‐limiting enzyme in the kynurenine (Kyn) pathway of tryptophan (Trp) metabolism. IDO is immunosuppressive and is induced by inflammation in macrophages and dendritic cells (DCs). Previous studies have shown the serum Kyn/Trp levels in patient