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Modulation of IL-2, IFN-γ, TNF-α and IL-4 production in mice of different ages by thymopentin

✍ Scribed by Enrico Cillari; Salvatore Milano; Renata Perego; Gianni Gromo; Rita D'Agostino; Francesco Arcoleo; Maria Dieli


Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
487 KB
Volume
14
Category
Article
ISSN
0192-0561

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IL-4 specifically induced IgE production by peripheral blood lymphocytes or by tonsil or spleen cells from healthy donors. IL-4-induced IgE synthesis was dependent on CD4+ T cells and monocytes and was blocked by IFN-y, IFN-a, and prostaglandin E-2 (PGE-2). These substances also inhibited IL4-induce