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Effect of isoprinosine on IL-2, IFN-γ and IL-4 production in vivo and in vitro

✍ Scribed by Salvatore Milano; Maria Dieli; Stephanie Millott; M. Dora Miceli; Elvira Maltese; Enrico Cillari


Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
398 KB
Volume
13
Category
Article
ISSN
0192-0561

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IL-4 specifically induced IgE production by peripheral blood lymphocytes or by tonsil or spleen cells from healthy donors. IL-4-induced IgE synthesis was dependent on CD4+ T cells and monocytes and was blocked by IFN-y, IFN-a, and prostaglandin E-2 (PGE-2). These substances also inhibited IL4-induce