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Modulation of human α1(I) procollagen gene activity by interaction with Sp1 and Sp3 transcription factors in vitro

✍ Scribed by Shu-jen Chen; Carol M. Artlett; Sergio A. Jimenez; John Varga


Book ID
117523174
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
147 KB
Volume
215
Category
Article
ISSN
0378-1119

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Interferon-␥ (IFN-␥), a multifunctional cytokine produced by activated Th1 lymphocytes, exerts potent effects on the extracellular matrix by regulating fibroblast function. In this study, we examined the modulation of ␣1(I) procollagen gene (COL1A1) expression by recombinant IFN-␥. The results showe