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Modulation of hepatocyte function by changing the cell shape in primary culture

✍ Scribed by Kazunobu Sawamoto; Naommy Takahashi

Book ID
107427499
Publisher
Society for In Vitro Biology
Year
1997
Tongue
English
Weight
617 KB
Volume
33
Category
Article
ISSN
1475-2689

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TGF-beta is a potent inhibitor of EGF-induced DNA synthesis in primary rat hepatocyte cultures. Norepinephrine (NE) was shown to modulate this inhibition of DNA synthesis. It produced a five-fold increase, from 2.8 pM to 14.4 pM, in the IDSo for TGF-beta. The effect was dose-dependent and was signif