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Modulation of Endogenous Smad Expression in Normal Skin Fibroblasts by Transforming Growth Factor-β

✍ Scribed by Yasuji Mori; Shu-Jen Chen; John Varga

Book ID
115603727
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
283 KB
Volume
258
Category
Article
ISSN
0014-4827

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The effect of transforming growth factor-type f3 l(TGF-P) on the growth and differentiation of normal human skin keratinocytes cultured in serum-free medium was investigated. TCF-P markedly inhibited the growth of keratinocytes at the concentrations >2 ng/ml under low Ca2+ conditions (0.1 mM). Growt