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Modulation of EGF binding and action by succinylated concanavalin A in fibroblast cell cultures

✍ Scribed by Ballmer, Kurt ;Burger, Max M.

Publisher: Wiley (John Wiley & Sons)
Year: 1980
Tongue: English
Weight: 338 KB
Volume: 14
Category: Article
ISSN: 0091-7419
DOI: 10.1002/jss.400140209

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✦ Synopsis

Abstract

The role of the binding of succinylated concanavalin A to tissue culture cells in influencing epidermal growth factor (EGF)‐mediated cell proliferation has been studied. Succinylated concanavalin A dramatically reduces the stimulation of 3T6 cells by EGF in Dulbecco's modified Eagle's medium (DME) containing insulin and vitamin B~12~ as additional growth factors, but no serum. Furthermore, binding studies using ^125^I‐labeled EGF have shown that the binding of EGF to the cell surface is reduced upon addition of succinylated concanavalin A.

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