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Modulation of cisplatin cytotoxicity by permeabilization of the plasma membrane by digitonin in vitro

✍ Scribed by Antti P. Jekunen; David R. Shalinsky; Doreen K. Hom; Kathy D. Albright; Dennis Heath; Stephen B. Howell


Book ID
115783142
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
823 KB
Volume
45
Category
Article
ISSN
0006-2952

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The yeast, Kluyveromyces fragilis was permeabilized to a number of low-molecular-weight substrates using digitonin. The activities of intracellular yeast enzymes, viz., alcohol dehydrogenase (ADH), beta-galactosidase, glucose-6-phosphate dehydrogenase, aspartase, and hexokinase were found to be much