Modulation of autoimmunity to beta-cell antigens by proteases
β Scribed by B. Roep; N. van den Engel; A. van Halteren; G. Duinkerken; S. Martin
- Book ID
- 105817226
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 99 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0012-186X
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## Abstract Apoptosis of autoaggressive Tβcells in the CNS is an effective, noninflammatory mechanism for the resolution of Tβcell infiltrates, contributing to clinical recovery in Tβcellβmediated neuroinflammatory diseases. The clearance of apoptotic leukocytes by tissueβspecific phagocytes is cri
The process of thymic selection is critical for the generation of the mature T-cell repertoire, yet the nature of the self-peptides that serve this function is not known. Several studies suggest that tissue-specific auto-antigens are expressed in the thymus. We initiated this study to examine the ex